Proteus

 

Publicaciones y referencias

Rodriguez-Navarro AJ, Lagos N, Lagos M, Braghetto I, Csendes A, Hamilton J, Berger Z, Wiedmaier G, Henriquez A (November 2006). "Intrasphincteric neosaxitoxin injection: evidence of lower esophageal sphincter relaxation in achalasia". American Journal of Gastroenterology 101(11):2667-8.

Rodriguez-Navarro AJ, Lagos N, Lagos M, Braghetto I, Csendes A, Hamilton J, Figueroa C, Truan D, Garcia C, Rojas A, Iglesias V, Brunet L, Alvarez F (February 2007). "Neosaxitoxin as a local anesthetic: preliminary observations from a first human trial". Anesthesiology 106(2):339-45.

Henkel G (February 2007). "This Month in Anesthesiology". Anesthesiology 106(2):5A-6A.

Epstein-Barash H, Shichor I, Kwon AH, Hall S, Lawlor MW, Langer R, Kohane DS (April 2009). "Prolonged duration local anesthesia with minimal toxicity". Proceedings of the National Academy of Sciences 106(17):7125-30.

Chorny M, Levy RJ. “Commentary. Site-specific analgesia with sustained release liposomes” (April 2009). Proceedings of the National Academy of Sciences 106(17):6891-2.

Rodriguez-Navarro AJ, Lagos M, Figueroa C, Garcia C, Recabal P, Silva P, Iglesias V, Lagos N (November 2009). "Potentiation of local anesthetic activity of neosaxitoxin with bupivacaine or epinephrine: development of a long-acting pain blocker". Neurotoxicity Research 16(4):408-15.

Ip VH, Tsui BC (January 2011). "Novelty without toxicity: a quest for a safer local anesthetic". Canadian Journal of Anaesthesia 58(1):8-13.

Rodríguez-Navarro AJ, Berde CB, Wiedmaier G, Mercado A, Garcia C, Iglesias V, Zurakowski D (March-April 2011). "Comparison of neosaxitoxin versus bupivacaine via port infiltration for postoperative analgesia following laparoscopic cholecystectomy: a randomized, double-blind trial". Regional Anesthesia and Pain Medicine 36(2):103-9.

Butterworth JF 4th (March-April 2011). “Will conventional local anesthetics soon be replaced by neurotoxins?”. Regional Anesthesia and Pain Medicine 36(2):101-2.

Wylie MC, Johnson VM, Carpino E, Mullen K, Hauser K, Nedder A, Kheir JN, Rodriguez-Navarro AJ, Zurakowski D, Berde CB (March 2012). "Respiratory, neuromuscular, and cardiovascular effects of neosaxitoxin in isoflurane-anesthetized sheep". Regional Anesthesia and Pain Medicine 37(2):152–8.

Vadhanan P, Adhinarayanan S (September 2014). Future local anesthetics: Neurotoxins? Anaesth Pain & Intensive Care 2014;18(3):308-12.

Zepeda RJ, Candiracci M, Lobos N, Lux S, Miranda HF (September 2014). Chronic toxicity study of neosaxitoxin in rats. Mar Drugs. 2014;12(9):5055-71.

Manríquez V, Castro Caperan D, Guzmán R, Naser M, Iglesia V, Lagos N (June 2015). “First evidence of neosaxitoxin as a long-acting pain blocker in bladder pain syndrome”. Int Urogynecol J. 2015;26(6):853-8.

Lahaye LA, Butterworth JF 4th (October 2015). “Site-1 Sodium Channel Blockers as Local Anesthetics: Will Neosaxitoxin Supplant the Need for Continuous Nerve Blocks?”. Anesthesiology. 2015;123(4):741-2.

Rathmell JP, Strichartz G, Wanderer J (October 2015). "Neosaxitoxin versus Traditional Local Anesthetics: Mechanism of Action and Sites of Notable Effect". Anesthesiology 2015;123(4):A23.

Lobo K, Donado C, Cornelissen L, Kim J, Ortiz R, Peake RW, Kellogg M, Alexander ME, Zurakowski D, Kurgansky KE, Peyton J, Bilge A, Boretsky K, McCann ME, Berde CB, Cravero J (October 2015). "A Phase 1, Dose-escalation, Double-blind, Block-randomized, Controlled Trial of Safety and Efficacy of Neosaxitoxin Alone and in Combination with 0.2% Bupivacaine, with and without Epinephrine, for Cutaneous Anesthesia". Anesthesiology 2015;123(4):873-85.

Templin JS, Wylie MC, Kim JD, Kurgansky KE, Gorski G, Kheir J, Zurakowski D, Corfas G, Berde C (October 2015). "Neosaxitoxin in Rat Sciatic Block: Improved Therapeutic Index Using Combinations with Bupivacaine, with and without Epinephrine". Anesthesiology. 2015;123(4):886-98.

 

Comunicados y Prensa

TIDO del Boston Children’s Hospital (scientific)

TIDO del Boston Children’s Hospital (economics)

TIDO Reporte Anual 2010

TIDO Reporte Anual 2011

Vector Blog 2011

BBC Mundo 2011

El Mercurio 2011

El Mercurio 2012

Economía y Negocios 2012

Diario Financiero 2012

Vector Blog 2013

Boston Magazine 2013

Medscape Medical News 2014

El Mercurio 2015